Targeted Therapy, Dabrafenib

Another ASCO update - Dabrafenib is a drug similar to Zelboraf (at least that is my understanding of it).

Target Therapy - www.cancer.net


Targeted Therapy, Dabrafenib, Keeps Melanoma From Worsening Longer Than Chemotherapy

Researchers found that the drug dabrafenib reduced the risk of melanoma worsening and the risk of death from the disease when compared with chemotherapy in a new, large study of melanoma. Dabrafenib is a targeted drug. This treatment targets the cancer’s specific genes, proteins, or the tissue environment that contributes to cancer growth and survival. Specifically, dabrafenib targets a mutation (change) in the BRAF gene, which is known to fuel melanoma growth. Another drug recently used for melanoma, vemurafenib (Zelboraf), also targets the BRAFmutation.
The patients who participated in this study had stage III or IV melanoma that could not be removed with surgery and had not received any treatment before the study began. During the study, they received either dabrafenib or a standard chemotherapy for melanoma, the drug dacarbazine (DTIC-Dome). Melanoma growth slowed or stopped for 50% of the patients taking dabrafenib, compared with 6% of those receiving chemotherapy. Because the study is ongoing, researchers do not have final data; they estimate that the time it takes for the melanoma to worsen for patients taking dabrafenib will be a little more than two months longer than for the patients receiving chemotherapy.
The side effects of dabrafenib include sensitivity to the sun and other skin cancers. However the number of patients who developed these side effects was low. In fact, the side effects of dabrafenib in this study were less severe than previous research on vemurafenib has shown.
What this means for patients
"For three decades, we had no new treatments for melanoma that had spread to other parts of the body. Last year, ipilimumab (Yervoy) and vemurafenib were approved, and now dabrafenib could be approved," explained lead author and global principal investigator, Axel Hauschild, MD, Professor of Dermatology at the University Hospital in Kiel, Germany. "These findings represent another advance in the treatment of melanoma.” Research on dabrafenib is ongoing, and it is currently only available in clinical trials. Talk with your doctor about all the treatment options for melanoma, including clinical trials.


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